Epithalon vs Pinealon
There is no winner on this page. What is set side by side is the published record behind each one, which is the part the two are rarely compared on.
Both in Longevity and bioregulators
Both are filed as pineal compounds and both run above the only human figures that exist. Epithalon's human record belongs to Epithalamin, a bovine pineal extract FDA states is a different substance, given as 10 mg into muscle daily for 10 days, which is digit for digit the circulating schedule for a different agent. Pinealon's inventors say it was taken from an extract of cattle brain cortex rather than pineal, and in the one rat pineal culture that tested both, the peptide that moved the pineal markers was Epithalon. Its swallowed convention runs a hundred times the one published human amount on that route.
| Field | Epithalon | Pinealon |
|---|---|---|
| What a trial gave | 0.5 mg a day, sprayed under the tongueIvko 2021, 20 women on a 20 day spray, the only randomised study of the four unit chain | 200 mcg a day, swallowed, for two weeksNazimko 2012, one 100 mcg capsule twice a day in locomotive crew, no participant count given |
| What circulates | 10 mg a dose under the skin, 50 or 100 mg a course, one to two times a year | 5 to 10 mg a day injected, or 10 to 20 mg swallowed |
| The gap | Above the studied dose | Above the studied dose |
| How long it lasts | I could not find one, in any species. The entry's author found no pharmacokinetic study of this compound at all, which is the kind of study that measures where a dose goes and how fast it disappears, so how long a dose lasts, whether the intact four unit chain survives being sprayed under the tongue or injected under the skin, and what fraction of it reaches any tissue are all unmeasured. | No figure has been published that I could find. I found no measurement of how much of it is absorbed, how long it lasts in the body, or what fraction of a dose ever reaches the blood, in any species. Khavinson's own 2022 review on how these very short peptides are carried into cells proposes transport routes and reports no such measurement. |
| Route studied | In people, three published studies: two sprays under the tongue in night shift workers, and one injection into the tissue around the eyeball. The only one of the three with a dose I could point to is 0.5 mg a day for 20 days under the tongue. In mice, injected under the skin, 1.0 microgram per mouse on five consecutive days each month. | Swallowed as capsules, one 100 microgram capsule twice a day for two weeks, in the only published paper I found that names a route. The 25 patient study printed inside the patent injected it into the muscle once a day for ten days. The animal work injected it into the belly cavity, which is a laboratory route and not one a person uses. |
| Route used | Injected under the skin, at home. The entry's author found no published study giving it to a human by that route, and it is the route the whole community convention runs on. | Injected under the skin, or swallowed. That is what the protocol pages list, not observed use. No human paper I found describes an injection, and the one that names a route used capsules. |
| Vial sizes | 10 mg | 10, 20 mg |
The distance, stated
Above the studied dose
Epithalon
Twenty times the only dose the four unit chain has been given a person, and by a route no published study was found using. Trace the 10 mg and it lands on the 2003 extract paper, whose St Petersburg cohort gave 10 mg into muscle daily for 10 days, 100 mg a course, digit for digit the circulating schedule. The agent in that trial was Epithalamin, a bovine pineal extract that FDA states is a different substance, and no vendor or clinic page was found deriving the 10 mg from any study of the chain itself.
Above the studied dose
Pinealon
The swallowed convention is a hundred times the one human amount I found in a published paper, on the same route: 200 micrograms a day against a vendor top end of 20 milligrams. The injected convention matches one published human figure only, and it is the 5 milligram arm reserved for the most severely injured in a ten day study I found inside a patent, whose mildest arm got 1 microgram. I found no page tracing its milligram figure to any study, and one says outright that the number was shaped by the product format and community habit rather than by a dose response trial.
What people get wrong
Epithalon
The costly mistake is the one letter. The 266 person survival paper, the 4.1 fold mortality figure and the later Kiev follow up are all real research on real patients, and every bit of it was done with Epithalamin, the cow pineal extract. Read the 266 carefully, though, because it is three cohorts added together rather than one trial of 266 people: 94 women at a St Petersburg veterans home split four ways, a separate 20 given both extracts every year for six years, and 152 people in Kiev split three ways on a different schedule. Everything in that paper went into muscle; the later Kiev follow up does not state a route. The famous 4.1 fold is the group of 20 against the St Petersburg control arm of 22, which in counts is 4 deaths against 18, and the arm on the extract alone, 24 patients, had a six year death rate of 45.8 percent, 11 deaths. Real randomisation, real numbers, small arms, different substance. The 10 mg figure comes from the same paper: its St Petersburg cohort gave 10 mg into muscle daily for 10 days, 100 mg a course, which is the circulating Russian schedule digit for digit, and its Kiev cohort gave 10 mg into muscle in five doses, 50 mg a course, which is the other circulating one. The entry's author found no vendor or clinic page that derives that 10 mg from any study of the four unit chain.
Pinealon
Two things get mixed up, and they stack. The first is the gland. The name reads as a pineal compound and it is filed next to Epithalon on that basis, while its inventors say it was taken from an extract of cattle brain cortex, and in the one rat pineal gland culture I found that tested both, the peptide reported to move the pineal markers was Epithalon and not this one. The second is what stands behind the human numbers. The main English language review of it makes two claims about people, and following its own citations leads to another review and to a patent, so a reader who expects a trial report does not find one.
Every figure above is carried across from each compound’s entry, which is where the citations live.
All 65 compounds on one page at what circulates vs what was studied, or pick another two to compare.