The Longevity Desk

A longevity newsletter

Longevity research, read closely and reported straight.

Most of what gets sold as longevity is marketing with a lab coat on. This is the opposite: what the evidence actually supports, what it doesn’t, and an honest answer when nobody knows yet.

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The three pillars

Why these three →

Heart disease, type 2 diabetes and Alzheimer’s look like separate problems. Follow each one down far enough and you arrive at the same three failures — which reinforce each other.

  1. 01Chronic inflammationInflammation that never resolves. Implicated in cardiovascular disease, diabetes, autoimmune conditions, several cancers, and cognitive decline.
  2. 02Insulin resistanceCells stop responding to insulin, and the body compensates by making more of it. It can hide behind normal blood sugar for a decade or more.
  3. 03Mitochondrial dysfunctionThe cell's power plants produce less energy than they used to. The tissues that need the most energy feel it first.

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