The Longevity Desk

Reference

What circulates, and what was actually studied

Every compound on this site in one table, so the comparison can be read in one pass instead of sixty-five.

65 compounds26 with no dose to compare against9 run above it13 below17 land on it

Every figure here is carried across from that compound’s entry, which is where the citations live. Where a convention has no derivation behind it, the row says so rather than leaving the column blank. Each name links to the card, and the card links to the entry.

This is not a protocol and there is no dose to follow here. The studied column is what a trial administered to people under supervision. The circulating column is what gets reported in practice, recorded because it is what happens, not because it is endorsed. The distance between the two is the only claim this table makes.
CompoundWhat a trial gaveWhat circulatesHow they compare
Recovery and tissue repair
BPC-157Never an approved medicineAbout 117 mcg per dayAllometric scaling from the 10 µg/kg rat arm, FDA body surface method250 to 500 mcg per dayPeople take more than any study gave
TB-500Never an approved medicineNo human dose has ever been publishedFDA found no article administering it to a human2 mg twice weekly, then weeklyNothing to compare against
GHK-CuNever an approved medicineNo injection into a person that I could findEvery published human study applied it to skin, and the 1994 gel's strength is not stated1 to 2 mg a day under the skin, some say 3Nothing to compare against
KPVNever an approved medicineNo human dose has ever been publishedThe only figure in the literature is 16 mcg/kg/day in mice, by feeding tube200 to 400 mcg a day injected, 250 mcg twice daily by mouthNothing to compare against
Metabolic and GLP-1
SemaglutideAn approved medicine existsLarge randomised placebo controlled trialsThe strongest evidence base of anything on this sitePrescription doses, often from grey market vialsMatches an amount a study gave
TirzepatideAn approved medicine exists5, 10 and 15 mg weeklySURMOUNT-1, about a fifth of body weight at the top doseMicrodoses below 2.5 mg weeklyPeople take less than studies gave
RetatrutideIn drug trials, approved nowhereUp to 12 mg weeklyLilly phase 2, about a quarter of body weight at the top dose0.25 to 1.5 mg starting, 4 mg maintenancePeople take less than studies gave
NAD+Never an approved medicine10 mg a day into a vein, for seven daysYu 2026, 180 adults with damaged hearts, the only study sized for an outcome250 to 1000 mg a session into a vein, 100 to 500 mg under the skinPeople take more than any study gave
5-Amino-1MQNever an approved medicineNo human dose I could find, by any routePubMed, ClinicalTrials.gov, the EU register and Europe PMC, no human study in any of them50 to 150 mg a day by mouth, convention rather than evidenceNothing to compare against
AOD-9604Never an approved medicine0.25, 0.5 and 1 mg a day, swallowedMETAOD006, the phase 2b in 502 adults over 24 weeks, which missed300 mcg a day under the skin, inside a 250 to 500 mcg bandMatches an amount a study gave
CagrilintideIn drug trials, approved nowhere0.3 to 4.5 mg a week, including 2.4 mgLau 2021 in 706 adults, plus single agent arms of 302 and 152 in two phase 3 trials2.4 mg a week from a 0.25 mg start, or up to 4.5 mgMatches an amount a study gave
MazdutideAn approved medicine exists4 mg and 6 mg weekly, for 48 weeksGLORY-1, 610 Chinese adults, the trial the weight approval was built on2.5 mg weekly for four weeks, then 5 mg weeklyMatches an amount a study gave
TesofensineNever an approved medicine0.25, 0.5 and 1.0 mg by mouth, once dailyAstrup 2008, TIPO-1, 203 obese adults over 24 weeks0.25 mg to 0.5 mg by mouth, once dailyMatches an amount a study gave
L-Carnitine, injectableAn approved medicine exists4 grams a day, into a veinZhang 2014, 30 patients with metabolic syndrome, inside a five day modified fast250 to 1,000 mg into muscle, or a drip with no stated dosePeople take less than studies gave
Growth hormone
IpamorelinNever an approved medicineAbout 4.2 mg per day, into a veinThe published Helsinn trial, which missed its endpoint200 to 900 mcg per day, under the skinPeople take less than studies gave
CJC-1295Never an approved medicine30 to 60 mcg/kg, about 2.25 to 4.5 mgTeichman 2006, trials of 28 and 49 days1 to 2 mg per week, DAC versionPeople take less than studies gave
MK-677In drug trials, approved nowhere25 mg, the top of three armsA 1996 dose ranging study in 32 people aged 64 to 8110 to 25 mg once dailyMatches an amount a study gave
TesamorelinAn approved medicine exists2 mg a day, continuously, for 26 weeks to a yearFalutz 2007 in 412 adults with HIV, plus three later trials at the same dose2 mg a day, from grey market vials, run in cyclesMatches an amount a study gave
SermorelinWas approved; product gone2 mg nightly, or 2,000 mcgVittone 1997, the only adult treatment study the author could find, 11 men, six weeks, no control group200 to 300 mcg under the skin nightly, titrated toward 500 mcgPeople take less than studies gave
GHRP-2An approved medicine exists100 mcg, one injection into a veinThe Japanese label, marketed since February 2005: one slow injection into a vein, given fasting, for the diagnosis of growth hormone secretion deficiency. The nearest repeated dosing is Nijland, 100 mcg under the skin once daily for five days in nine healthy young men.100 to 300 mcg per injection under the skin, one to three times daily, most commonly 200 mcgPeople take more than any study gave
GHRP-6Never an approved medicine1 mcg/kg into a vein, about 80 to 100 mcgBowers 1990, 18 normal men, and the same dose and route reused exactly in five later studies100 to 300 mcg under the skin, two to three times dailyMatches an amount a study gave
HexarelinNever an approved medicine1.5 mcg/kg twice daily, about 210 mcg a day at 70 kgRahim, O'Neill and Shalet, 12 healthy elderly people, 16 weeks under the skinAbout 100 mcg an injection under the skin, two to three times daily for 200 to 300 mcg a day, several call 200 mcg twice daily standard and some go higherMatches an amount a study gave
IGF-1 LR3Never an approved medicineNo dose in a person that I could findI found no study giving it to a human being, and no registered trial. Across the records reviewed, every dose is an animal dose.Roughly 20 to 100 mcg a day under the skin, in cycles of about 4 to 6 weeksNothing to compare against
HGH Fragment 176-191Never an approved medicineNo human dose of the fragment was foundSix searches across four databases on 2026-08-05 found no human study of it250 to 500 mcg a day under the skin in 8 to 12 week cycles, or 200 to 500 mcg fasted for about four weeksNothing to compare against
Follistatin-344Never an approved medicineNo study I found gave the protein to a person on its own, by any route93 PubMed clinical trial records and 79 registry studies searched, and every human study I found that gave follistatin gave a gene100 to 200 mcg a day under the skin, in cycles of 10 to 30 days, community convention not a tested doseNothing to compare against
PEG-MGFNever an approved medicineNo dose in a person, or in a live animal of any species, that I could findFDA states it has identified no human exposure data on PEG-MGF products by any route200 to 400 mcg two to three times a week, and daily in the same rowNothing to compare against
Cognitive and neuro
SemaxAn approved medicine exists800 to 8,000 mcg, up the noseThe Russian 0.1 percent label500 to 3,000 mcg, usually injectedPeople take less than studies gave
SelankAn approved medicine existsNo trial has ever reported a doseThree Russian trials, 192 patients, no dose in any of them900 mcg a day from the drops, 1,350 quoted by vendorsNothing to compare against
CerebrolysinAn approved medicine exists10 to 50 mL a day into a vein, in patientsThe Austrian label's table by condition, and the stroke and dementia trials behind it5 to 10 mL a day, under the skin or into a musclePeople take less than studies gave
P-21Never an approved medicineNo dose in a person that I could findEvery dose in the record came from a mouse or a rat, by chow, a stomach tube, an implanted pellet or a shot into the abdomen500 mcg to 1 mg once daily, under the skinNothing to compare against
DSIPNever an approved medicineAbout 1,485 mcg into a vein, for a 70 kg adult25 nmol/kg, or 21.2 mcg/kg, the dose most of the human sleep trials used100 to 300 mcg under the skin, once in the eveningPeople take less than studies gave
DihexaNever an approved medicineNo dose in a person that I could findEvery human figure belongs to fosgonimeton, dihexa with a phosphate group added so it can be injectedAbout 5 to 50 mg a day by mouth across vendor and community pages, no two agreeingNothing to compare against
PE-22-28Never an approved medicineNo human dose I could find, by any routeEvery published dose is in a mouse: 3.0 to 4.0 mcg/kg into the abdominal cavity, and 1 mg/kg by tube into the stomach in one panel100 to 2,000 mcg per dose, mostly up the noseNothing to compare against
Mitochondria and cellular energy
MOTS-cNever an approved medicineNo human dose has ever been publishedEvery published dose is a mouse dose, 0.5 to 15 mg per kg per day5 to 10 mg per dose, two or three times a week up to dailyNothing to compare against
SS-31An approved medicine exists40 mg a day under the skinFive published trials and the approved label, every one in people with a diagnosed disease0.1 to 40 mg a day under the skinPeople take less than studies gave
HumaninNever an approved medicineNo human dose I could find, by any routeEvery published dose is an animal dose. Yen 2020 gave 100 mice the analogue S14G at 4 mg per kg into the abdominal cavity0.1 mg to 10 mg per dose under the skin, two or three times a week up to dailyNothing to compare against
SLU-PP-332Never an approved medicineNo human dose I could find, by any routeFour mouse studies, 25 to 50 mg per kg into the abdominal cavity250 mcg to 1.5 mg a day under the skin, or 1 to 5 mg, or 400 to 800 mg by mouthNothing to compare against
BAM-15Never an approved medicineNo published human dose I could find, at any routeAll 72 PubMed records retrieved and every title read; the doses in them are mice, flies and worms10 micrograms to 60 mg a day, depending on the pageNothing to compare against
AICARNever an approved medicine42 mg per kg into a vein, about 2,940 mg at 70 kg, onceRED-CABG, 3,080 adults having heart surgery, stopped for futility1 to 25 mg a day under the skin, on pages that disagreePeople take less than studies gave
Longevity and bioregulators
EpithalonNever an approved medicine0.5 mg a day, sprayed under the tongueIvko 2021, 20 women on a 20 day spray, the only randomised study of the four unit chain10 mg a dose under the skin, 50 or 100 mg a course, one to two times a yearPeople take more than any study gave
PinealonNever an approved medicine200 mcg a day, swallowed, for two weeksNazimko 2012, one 100 mcg capsule twice a day in locomotive crew, no participant count given5 to 10 mg a day injected, or 10 to 20 mg swallowedPeople take more than any study gave
FOXO4-DRINever an approved medicineNo dose in a person that I could findEvery animal dose I could read is 5 mg per kilogram, in mice25 mg into a vein three times, or 250 to 500 mcg dailyNothing to compare against
Glutathione, injectableNever an approved medicine600 mg twice a day, and 1,400 mg three times a week, into a veinTwo Parkinson's disease studies: nine patients uncontrolled, and 21 randomised at P = 0.32600 to 1,400 mg per session, two to three times a weekMatches an amount a study gave
Immune and thymic
Thymosin Alpha-1An approved medicine exists1.6 mg under the skin, twice weekly, and every 12 hours in sepsisThe Italian label's own dosing table, 900 micrograms per square metre of body surface1.6 mg under the skin, twice weeklyMatches an amount a study gave
ThymalinAn approved medicine exists10 mg a day for 5 to 10 days, injected into a muscleThe Russian label, and every published human use I could open across 25 years10 mg a day for 5 to 10 days, injected under the skinMatches an amount a study gave
LL-37Never an approved medicine0.5 to 3.2 mg per mL on a wound, and 250 to 500 micrograms into each tumourThree randomised wound trials and one melanoma injection trial100 to 250 micrograms a day under the skin, some pages to 500Nothing to compare against
VIPAn approved medicine exists50 micrograms four times a day, inhaled through a nebuliserEight pulmonary hypertension patients in 2003, and 20 sarcoidosis patients in 201050 micrograms per spray, four times a day, into the noseMatches an amount a study gave
ARA-290Never an approved medicine4 mg a day under the skin for 28 daysA 64 patient sarcoidosis trial, and a 10 volunteer exposure study behind the number4 mg a day under the skin, in blocks of four weeks and longerMatches an amount a study gave
Melanocortin and hormonal
Melanotan IINever an approved medicine0.025 mg/kg, about 1.75 mg for a 70 kg adultRecommended by the 1996 phase I and used in all three later trials. Four trials, 43 men, 1996 to 2000.250 to 500 mcg daily to load, some to 1,000 mcg, then 500 mcg twice weekly or 250 mcg once or twice weeklyPeople take less than studies gave
PT-141An approved medicine exists1.75 mg under the skin, in premenopausal womenTwo phase 3 trials, NCT02333071 and NCT02338960, in 1,267 premenopausal women. The only published male efficacy doses under the skin were 4 mg and 6 mg, in men sildenafil had not helped.1.0 to 2.0 mg under the skin in men, reported as conventionMatches an amount a study gave
Melanotan IAn approved medicine exists16 mg in a rod placed under the skin every two monthsThe approved implant, in patients with a rare light sensitivity disease1 mg a day for 10 days, then 2 mg a week, injectedMatches an amount a study gave
OxytocinAn approved medicine existsA drip into a vein, or ten units into a muscle after deliveryThe Pitocin label, which permits exactly those two routes24 units by nose, and 100 to 500 micrograms under the skinPeople take more than any study gave
Kisspeptin-10Never an approved medicine0.31 micrograms per kilogram into a vein, about 22 mcg for an adultFDA's record of the commonest studied intravenous bolus dose50 to 500 micrograms under the skin, 100 to 200 commonestPeople take more than any study gave
GonadorelinAn approved medicine exists100 micrograms as a single diagnostic injection, or 5 to 20 per pulseThe British diagnostic licence, and the Canadian pump licence100 micrograms under the skin, two or three times a weekMatches an amount a study gave
SARMs
RAD-140In drug trials, approved nowhere50 to 150 mg a day, with 100 mg set as the maximum toleratedA completed phase 1 in women with metastatic breast cancer20 to 30 mg a day for men, on an eight week cyclePeople take less than studies gave
RAD-150Never an approved medicineNothing, in any speciesSearched under RAD-150, RAD150 and TLB-150 on 10 August 2026Sold as a RAD-140 ester. I found no dosing figure traceable to anythingNothing to compare against
LGD-4033Never an approved medicine1.0 mg a day for 21 days, and 2.0 mg a day for 12 weeksA phase 1 in 76 healthy men and a phase 2 in 108 hip fracture patients10 mg a day for men over 8 to 10 weeks, up to 15 for experienced usersPeople take more than any study gave
LGD-3033Never an approved medicineNothing, in any speciesSearched under LGD-3033 and LGD3033 on 10 August 2026I found no dosing figure traceable to anythingNothing to compare against
MK-2866Never an approved medicine3 mg a day for 147 days in the phase 3 trialsTwo completed phase 3 trials in people starting chemotherapy10 to 25 mg a day, reported as the commonest range on guide pagesPeople take more than any study gave
YK-11Never an approved medicineNothing in a personCell work in 2011, and one mouse study in bacterial sepsisI found no dosing figure I could trace to a sourceNothing to compare against
S4Never an approved medicineNothing in a personA 2024 review reports its preclinical work was suspended before phase 1I found no dosing figure I could trace to a sourceNothing to compare against
S23Never an approved medicineNothing in a personRat work, injected under the skin, not swallowedI found no dosing figure I could trace to a sourceNothing to compare against
AC-262Never an approved medicineNothing in a personOne primary pharmacology paper, in castrated male rats over two weeksI found no dosing figure I could trace to a sourceNothing to compare against
SR-9009Never an approved medicine100 mg per kilogram, injected into the belly cavity, in miceThe two mouse studies the selling rests on, both by injection10 to 40 mg a day, with an instruction to redose every two to four hoursNothing to compare against
GW-0742Never an approved medicineA single 15 mg dose by mouth, in a doping control excretion studyNot an efficacy trial; it measured how long the compound stays detectableI found no dosing figure I could trace to a sourceNothing to compare against

This table is also a dataset: CSV or JSON, one row per compound with each row carrying the URL of the page that explains and cites its figures. Licensed CC BY 4.0, so use it freely with attribution.

The same sixty-five as cards, where each comparison is explained rather than only marked, or any two side by side.